Effects of stroke severity and treatment duration in normobaric hyperoxia treatment of ischemic stroke
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چکیده
منابع مشابه
Effects of stroke severity and treatment duration in normobaric hyperoxia treatment of ischemic stroke.
In order to improve clinical trial design and translation of normobaric oxygen (NBO) treatment of ischemic stroke, NBO treatment parameters need to be better understood. This study investigated NBO treatment efficacy at two different stroke severities and two NBO treatment durations in rats. For the 60-min middle cerebral artery occlusion (MCAO), NBO treatment for 25 min and 150 min were studie...
متن کاملNormobaric hyperoxia treatment in acute ischemic stroke.
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متن کاملNormobaric hyperoxia-based neuroprotective therapies in ischemic stroke
Stroke is a leading cause of death and disability due to disturbance of blood supply to the brain. As brain is highly sensitive to hypoxia, insufficient oxygen supply is a critical event contributing to ischemic brain injury. Normobaric hyperoxia (NBO) that aims to enhance oxygen delivery to hypoxic tissues has long been considered as a logical neuroprotective therapy for ischemic stroke. To da...
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BACKGROUND The therapeutic time window for thrombolysis appears to be extremely short, probably because of the hemorrhagic complications associated with late reperfusion of ischemic brain tissue. Other neuroprotective forms of treatment continue to be developed, although their efficacy has yet to be conclusively proved in patients. The duration of treatment in recent phase 3 trials ranges from ...
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ژورنال
عنوان ژورنال: Brain Research
سال: 2016
ISSN: 0006-8993
DOI: 10.1016/j.brainres.2016.01.030